On sait que la migraine est associée à une pléthore de conditions comorbides dont l’épilepsie [26], la dépression [27], les troubles anxieux [28], certaines allergies [97], l’hypertension artérielle [301], et les accidents vasculaires cérébraux (AVC) [29]. En fait, jusqu’à 17% des AVC sous la barre des 50 ans seraient en lien avec la migraine [30]. Une revue de la littérature a également récemment démontré une augmentation de la prévalence du syndrome du côlon irritable chez les migraineux [314]. De façon moins certaine, il pourrait y avoir un lien également avec d’autres conditions gastro-intestinales ainsi que l’asthme. Les mécanismes sous-jacents ces derniers liens sont toutefois pour la plupart plus ou moins bien élucidés.
Abstract :
Objective . Even though evidence showing increased prevalence of irritable bowel syndrome (IBS) among migraine patients exists, it has not been well-established and the magnitude of association varies substantially across the studies. This study aimed to comprehensively compare the prevalence of IBS among migraineurs versus nonmigraineurs using the systematic review and the meta-analysis technique. Methods. Two authors independently conducted a literature search in MEDLINE, EMBASE and Google Scholar database up to April 2020. The eligible study must consist of two groups of participants, migraineurs and nonmigraineurs, and report the prevalence of IBS in both groups. Alternatively, an eligible study may report the odds ratio (OR) with a 95% confidence interval (CI) of the association between migraine and IBS. Point estimates and standard errors from each eligible study were combined together using the generic inverse variance method of DerSimonian and Laird. Results. Of the 2531 articles identified from the three databases, 11 studies with a total of 28 336 migraineurs and 1 535 758 nonmigraineurs met the selection criteria and were included into the meta-analysis. The pooled analysis found that migraineurs had a significantly higher prevalence of IBS than nonmigraineurs with the pooled OR of 2.49 (95% CI, 2.22–2.78; I2, 42%). The funnel plot was asymmetric and suggested the presence of publication bias. Conclusion. A significantly increased prevalence of IBS among patients with migraine was demonstrated in this study.
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